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EC number: 807-754-7
CAS number: 89929-57-7
of the test substance
mean tr (n=2)
Benzoic acid phenylester
Test substance – peak 1
8.2 x 102
adsorption coefficient (Koc) for the test substance was determined
according to OECD 121 guideline with GLP compliance. The HPLC method
using soil-adsorption-reference data was applied for the determination
of the adsorption coefficient (Koc) of test substance. To increase the
resolution, UPLC was used instead of HPLC.
column temperature of 35 ± 1 °C with a mobile phase consisting of 55 %
methanol and 45 % water. A 10.1 mg/L sample of the test substance was
analyzed using UPLC method. Solutions of reference substances with known
log Koc values based on soil adsorption data and the test substance were
analysed. Calibrations were performed using 8 reference items; retention
times, capacity factors (k') and log k’ values of the references
substances were plotted against the known log Koc values. Dead
time of the UPLC-system was determined with Formamide. The
retention times, capacity factor and log10 Koc value determined for the
test substance at a constant UPLC column temperature of 35 ± 1 °C.
pKa values for acidic and basic groups in the molecular structure of the
test substance in the logarithm range of 1 − 14 were calculated. The
equation of the regression line was: log k’ = 0.324 × log Koc – 0.853 (r
= 0.98, n = 16).
adsorption coefficient (Koc) and
log Koc of
the test substance at neutral pH was: 820
and 2.9, respectively.
OECD Guideline 121, EU Method C.19,
GLP, key study, validity 1:
log Koc = 2.9 for soil
Koc = 820 for soil
The mobility of the substance in soils is
considered as low (according to the criteria developed by P.J. McCall et
To assess the adsorption potential of the
registered substance on soil and on sewage sludge, one key study is
This study (WIL, 2015) was performed on the
registered substance according to OECD Guideline 121 and EU Method C.19
(HPLC screening method) under GLP conditions. According to this study,
the adsorption coefficient log Koc of the registered substance was
determined at 2.9 for soil. The results indicate that the substance has
low mobile in soils (according to P.J. McCall et al., 1981).
McCall P.J., Laskowski D.A., Swann R.L., and
Dishburger H.J., (1981), “Measurement of sorption coefficients of
organic chemicals and their use, in environmental fate analysis”, in
Test Protocols for Environmental Fate and Movement of Toxicants.
Proceedings of AOAC Symposium, AOAC, Washington DC.
Mobility classification scheme:
0 - 50
50 - 150
150 - 500
500 - 2000
2000 - 5000
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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