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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 January 2014 to 16 January 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised with its purity. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry
Specific details on test material used for the study:
- Storage condition of test material: In refrigerator (2-8°C) protected from light, container flushed with nitrogen
- Stability at higher temperatures: Yes, maximum temperature: 40°C, maximum duration: 10 days
Temp.:
20 °C
Vapour pressure:
5.8 Pa
Key result
Temp.:
25 °C
Vapour pressure:
11 Pa
Key result
Transition / decomposition:
no

Table 4.6/1: Results of the isothermal TGA analysis

 

Temperature [°C]

Weight loss [μg/min]

νT [g/cm2/h] 

log νT 

log PT 

PT [Pa]

25

6.451

7.70 x 10-4

-3.11

1.01

10

7.276

8.69 x 10-4

-3.06

1.07

12

30

12.25

1.46 x 10-3

-2.83

1.33

22

12.64

1.51 x 10-3

-2.82

1.35

22

35

20.70

2.47 x 10-3

-2.61

1.60

40

21.13

2.52 x 10-3

-2.60

1.61

41

40

32.79

3.91 x 10-3

-2.41

1.83

68

33.98

4.06 x 10-3

-2.39

1.85

71

 

Table 4.6/2: Vapour pressure of the test substance

 

Temperature [°C]

log PT

PT [Pa]

PT [mmHg]

20

0.76

5.8

4.3 x 10-2

25

1.05

11

8.4 x 10-2

The equation of the curve was: log PT = -5012 × 1/T + 17.86 (r = 0.997, n = 8).

Conclusions:
Low volatility (based on volatility bands criteria for occupational exposure (Chesar / ECETOC TRA), << 500 Pa).
Executive summary:

The vapour pressure of the test substance was measured, under GLP, according to OECD 104 / EU A4 guideline, using the isothermal thermogravimetric effusion method.

The system was calibrated with five reference substances, with VP between 1.33 E-8 and 2.34 E+3 Pa at 20°C, as a linear regression.

Isothermal TGA analysis of the test substance was performed between 25 °C and 40 °C. The vapour pressure of the test substance at 20°C and 25°C were determined using the vapour pressure regression curve.

The vapour pressure of the test substance at 20 °C (293 K) and 25 °C (298 K) was 5.8 Pa (4.3 × 10-2 mm Hg) and 11 Pa (8.4× 10-2 mm Hg), respectively.

Description of key information

Low volatility.

Key value for chemical safety assessment

Vapour pressure:
11 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study. The interpolated result at 25°C is retained as key value.