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EC number: 823-920-1
CAS number: 5341-95-7
Conducted as part of reproduction study; no definitive
dose-related teratological findings in either soft or
skeletal tissue. Fetotoxicity(e.g., delayed ossification of
sternebrae) noted at 10% and 24% doses, 5000 and 12000 mg/kg bw/d,
Incidence of fetal skeletal abnormalities in F3B generation:
*: significantly different from respective control, p </= 0.025
**: significantly different from respective control, p </= 0.01
Resorption and implantation data for F3B generation:
Teratogenic effects of 1,3-butylene glycol were investigated as part of
a multigeneration study in rats receiving 0, 5, 10 and 24% 1,3-butylene
glycol in the diet (0, 2500, 5000, 12000 mg/kg bw/d). No conclusive
teratogenic effects were seen in pups of the F3B generation at levels up
to 12000 mg/kg bw/d 1,3-butylene glycol in the diet. Incomplete
sternebral ossification at mid- and high-dose levels and missing
sternebrae at high-dose level were noted, probably indicating slight
delayed development of fetal skeletal tissue. The NOAEL for fetotoxicity
was 2500 mg/kg bw/d of 1,3-butylene glycol in the diet (Hess et al.,
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