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EC number: 823-920-1
CAS number: 5341-95-7
Acute aquatic ecotoxicity
Algae: 72h-ErC50 (Pseudokirchneriella subcapitata, growth rate) > 100
Daphnia: 48h-EC50 (Daphnia magna, mobility) > 100 mg/L (nominal),
48h-EC50 (Daphnia magna, mobility) >= 147 mg/L (extrapolated)
Fish: 96h-LC50 (Pimephales promelas) = 2830 mg/L (in silico)
Chronic aquatic ecotoxicity
72h-NOErC (Pseudokirchneriella subcapitata, growth rate) >= 100 mg/L
Activated sludge microorganisms: 30min- EC50 > 1000 mg/L (nominal)
Acute aquatic ecotoxicity
Available experimental and in silico data shows no or very low acute
toxicity of the submission substance. No adverse effects were observed
for algae and fish. Very low effects of mobility were observed in
aquatic invertebrates at high concentrations. The overall conclusion is
that the submission substance is of no or very low acute toxicity. The
most sensitive species is Daphnia magna among the available test data.
Short-term toxicity to aquatic algae
The available key study investigated growth inhibition of 2,3
-butanediol((2R,3S)-rich) to the Green Alga, Pseudokirchneriella
subcapitata. The study was conducted in accordance with the OECD No. 201
and in compliance with GLP. A limit test was performed at 100 mg/L test
item under static test conditions, using 6 replicates for control and
No negative effects on growth rate or yield of biomass were observed in
any of the test cultures. Moreover, no abnormalities were detected in
any of the cultures and there was no sign of contamination by foreign
algal cells or protozoa. The derived 72-hr EC50 was >100 mg/L (nominal)
for average growth rate and yield. The No Observed Effect Concentration
(NOEC) and Lowest Observed Effect Concentration (LOEC) were >= 100 mg/L
(nominal) and >100 mg/L (nominal) for average growth and yield.
The study fulfilled the all validity criteria of the guideline, and was
considered adequate and reliable for the environmental hazard assessment.
Short-term toxicity to aquatic invertebrates
In the available key study, acute toxicity to aquatic invertebrate
Daphnia magna was investigated. The study was performed according to
OECD guideline 202 (adopted 1984) and in compliance with GLP. No
immobility of daphnids was observed at test concentrations 0 (control),
12.5 and 20 mg/L during exposure period of 24 hours and 48 hours. One
daphnid was observed immobile at 50 mg/L after 48 hours of exposure, and
two daphnids were observed immobile at 100 mg/L after 48 hours. The
derived effect concentration was: 48h-EC50 (Daphnia magna, immobility) >
100 mg/L. Based on the new dose-response assessment of MOSAIC
Surv-Standard, the 48h-EC50 value was estimated (extrapolated) at 147
mg/L (95% CI: 112 - 240). The validity criteria of the test guideline
(adopted 1984) were fulfilled. Despite of some deficiencies with respect
to the updated guideline, the study was considered adequate and reliable
for environmental hazard assessment.
Short-term toxicity to fish
Acute toxicity of (2R,3S)-butane-2,3-diol to fish was predicted using
the OECD QSAR Toolbox 4.2 automated workflow (data gap filling method:
trend analysis, executed via Automated "Ecotoxicological Endpoint"). The
estimated lethal concentration (96h-LC50) was 2830 mg/L for Pimephales
promelas. Therefore, (2R,3S)-butane-2,3-diol is not expected to pose an
acute toxic hazard to fish. The prediction was considered reliable and
adequate for aquatic hazard assessment.
Chronic aquatic ecotoxicity
Long-term experimental data is available for algae. No negative effects
on algae growth were observed over 72 house exposure period. Based on
the available acute toxicity data with indication of low acute toxicity
at high concentrations, no or only very low chronic toxicity potential
may is expected. Furthermore, the submission substance is well soluble
in water and the rapidly degradable. Therefore, potential long-term
effects are out-ruled from substances with low water solubility and if
released into water, the submission substance will be degraded fast.
Therefore, no further testing was considered necessary.
Long-term toxicity to aquatic algae
Refer to Short-term toxicity to aquatic algae above.
In the available key study respiration inhibition of activated sludge
microorganisms was investigated according to OECD guideline 209 (adopted
1993). Domestic activated sludge was used as inoculum. No inhibition of
respiration was observed under static test conditions. The effect
concentrations EC20 and EC50 (respiration inhibition) were derived at >
1000 mg/L after 30 minutes of exposure. In conclusion, the test
substance was considered to not inhibit respiration of activated sludge
microorganisms. The validity criteria of the test guideline (adopted
1993) were fulfilled. Despite of some deficiencies with respect to the
updated guideline, the study was considered adequate and reliable for
environmental hazard assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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