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EC number: 823-920-1
CAS number: 5341-95-7
After the intradermal induction
intense erythema and swelling were observed at the injection sites of
all control group animals and all test group animals at which only
Freund's adjuvant/0.9% aqueous NaCI-solution was applied. At the
injection sites of a 5% test substance preparation in Freund's
adjuvant/0.9% aqueous NaCI-solution intense erythema and swelling were
seen in all test group animals. Injections of a 5% test substance
preparation in 0.9% aqueous NaCI-solution caused moderate and confluent
erythema and swelling in all test group animals. The control group
animals, injected with 0.9% aqueous NaCI-solution did not show any skin
reaction. A 50% formulation of 0.9% aqueous NaCI-solution with Freund's
adjuvant/0.9% aqueous NaCI-solution caused intense erythema and swelling
in all control group animals. The epicutaneous induction with a 50% test
substance preparation in doubly distilled water led to incrustation,
partially open (caused by the intradermal induction) and moderate and
confluent erythema with swelling in all test group animals.
The challenge with a 25% test
substance preparation in doubly distilled water did not cause any skin
reactions neither in control group 1 nor in the test group 24 and 48
hours after removal of the patches. Since no borderline results were
observed, a 2nd challenge was not performed. Control group 2, that had
been intended for a potential 2nd challenge was not applied and
therefore not reported.
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