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Diss Factsheets
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EC number: 202-491-9 | CAS number: 96-23-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: report of occupational exposure
Data source
Reference
- Reference Type:
- publication
- Title:
- Fulminant hepatitis following exposure to dichlorohydrin- Report of 2 cases
- Author:
- Shiozaki T et al
- Year:
- 1 994
- Bibliographic source:
- Hum. Exp Toxicol 13: 267-270
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Report of result of occupational exposure to the substance
- GLP compliance:
- no
- Remarks:
- Occupational exposure
- Test type:
- other: Occupational exposure
- Limit test:
- no
Test material
- Reference substance name:
- 1,3-dichloropropan-2-ol
- EC Number:
- 202-491-9
- EC Name:
- 1,3-dichloropropan-2-ol
- Cas Number:
- 96-23-1
- Molecular formula:
- C3H6Cl2O
- IUPAC Name:
- 1,3-dichloropropan-2-ol
- Test material form:
- liquid
1
Test animals
- Species:
- other: human
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: mortality following occupational exposure
- Remarks on result:
- other: mortality following occupational exposure
- Mortality:
- Two of the five died from hepatic failure four and 11 days after the job
- Gross pathology:
- Autopsy showed
submassive hepatocellular necrosis in one of the individuals - Other findings:
- In five of 12 workers exposed to an unknown concentration of 1,3-DCP (via inhalation) from the
cleaning of a saponification tank used in the manufacture of 1,3-DCP, acute hepatitis developed.
Any other information on results incl. tables
In five of 12 workers exposed to an unknown concentration of 1,3-DCP (via inhalation) from the
cleaning of a saponification tank used in the manufacture of 1,3-DCP, acute hepatitis developed.
Two of the five died from hepatic failure four and 11 days after the job. Autopsy showed
submassive hepatocellular necrosis in one of the individuals (e.g., total bilirubin levels were
significantly increased). At ~48 hours after exposure, the 1,3-DCP plasma level was 200 ng/mL.
Potential exposure to other chemicals was not reported
Applicant's summary and conclusion
- Interpretation of results:
- other: mortality following occupational expoaure
- Conclusions:
- In five of 12 workers exposed to an unknown concentration of 1,3-DCP (via inhalation) from the
cleaning of a saponification tank used in the manufacture of 1,3-DCP, acute hepatitis developed.
Two of the five died from hepatic failure four and 11 days after the job. Autopsy showed
submassive hepatocellular necrosis in one of the individuals. The substance is toxic by inhalation and/or dermal exposure.
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