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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: report of occupational exposure

Data source

Reference
Reference Type:
publication
Title:
Fulminant hepatitis following exposure to dichlorohydrin- Report of 2 cases
Author:
Shiozaki T et al
Year:
1994
Bibliographic source:
Hum. Exp Toxicol 13: 267-270

Materials and methods

Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Report of result of occupational exposure to the substance
GLP compliance:
no
Remarks:
Occupational exposure
Test type:
other: Occupational exposure
Limit test:
no

Test material

1
Chemical structure
Reference substance name:
1,3-dichloropropan-2-ol
EC Number:
202-491-9
EC Name:
1,3-dichloropropan-2-ol
Cas Number:
96-23-1
Molecular formula:
C3H6Cl2O
IUPAC Name:
1,3-dichloropropan-2-ol
Test material form:
liquid

Test animals

Species:
other: human
Sex:
male

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
air

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
other: mortality following occupational exposure
Remarks on result:
other: mortality following occupational exposure
Mortality:
Two of the five died from hepatic failure four and 11 days after the job
Gross pathology:
Autopsy showed
submassive hepatocellular necrosis in one of the individuals
Other findings:
In five of 12 workers exposed to an unknown concentration of 1,3-DCP (via inhalation) from the
cleaning of a saponification tank used in the manufacture of 1,3-DCP, acute hepatitis developed.

Any other information on results incl. tables

In five of 12 workers exposed to an unknown concentration of 1,3-DCP (via inhalation) from the

cleaning of a saponification tank used in the manufacture of 1,3-DCP, acute hepatitis developed.

Two of the five died from hepatic failure four and 11 days after the job. Autopsy showed

submassive hepatocellular necrosis in one of the individuals (e.g., total bilirubin levels were

significantly increased). At ~48 hours after exposure, the 1,3-DCP plasma level was 200 ng/mL.

Potential exposure to other chemicals was not reported

Applicant's summary and conclusion

Interpretation of results:
other: mortality following occupational expoaure
Conclusions:
In five of 12 workers exposed to an unknown concentration of 1,3-DCP (via inhalation) from the
cleaning of a saponification tank used in the manufacture of 1,3-DCP, acute hepatitis developed.
Two of the five died from hepatic failure four and 11 days after the job. Autopsy showed
submassive hepatocellular necrosis in one of the individuals. The substance is toxic by inhalation and/or dermal exposure.