Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 January 2018 - 17 January 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report Date:
2018

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
column elution method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Appearance: Off-white powder
- Storage condition of test material: At room temperature

Results and discussion

Water solubility
Key result
Water solubility:
3.99 mg/L
Temp.:
20 °C
pH:
>= 7.7 - <= 7.9
Remarks on result:
other: average of two runs
Details on results:
Mean concentration in the water samples (n=10) obtained at the flowrate of 24 mL/h was 3.97 mg/L. CV= 1.5%.
Mean concentration in the water samples (n=10) obtained at the flowrate of 12 mL/h was 4.01 mg/L. CV= 0.81%.
The maximum difference on the mean values at both flow rates was ≤ 30% (i.e. 1.0%). Average of two runs: 3.99 mg/L.
The coefficient of variation (CV) (n=10) was ≤ 30% at both flow rates. It demonstrated that the system was in equilibrium at all flow rates.

Any other information on results incl. tables

A small response at the retention time of the test item was detected in one of the two samples from the blank column at both flow rates. It was considered to have no impact on the results of the study.

.

Applicant's summary and conclusion

Conclusions:
The water solubility of the substance at 20°C was determined to be 3.99 mg/L.
Executive summary:

The water solubility of the substance was determined using the column elution method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840.

Quantification was performed by HPLC-MS/MS. The water solubility of the substance at 20°C was calculated as the average of two runs (24 mL/h and 12 mL/h) to be 3.99 mg/L. The pH of the aqueous samples was ca. 8.The coefficient of variation (n=10) was ≤ 30% at both flow rates. The maximum difference on the mean values at both flow rates was ≤ 30%.