Registration Dossier

Administrative data

Endpoint:
boiling point
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance is a solid which decomposes before boiling
Cross-reference
Reason / purpose:
data waiving: supporting information
Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 15 January 2018 to 01 May 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Version / remarks:
2016
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7200 (Melting Point / Melting Range)
Version / remarks:
1998
Deviations:
no
GLP compliance:
yes
Type of method:
differential scanning calorimetry
Key result
Melting / freezing pt.:
243.5 °C
Decomposition:
yes
Decomp. temp.:
300 °C

DSC EXPERIMENT 1

An endothermic peak was observed between 225°C and 250°C followed by an exothermic effect starting at 300°C (see the illustration below). The extrapolated onset temperature of the first peak was 243.512°C. The endothermic effect was most likely obtained due to melting of the test item. The exothermic effect was probably obtained due to reaction and/or decomposition of the test item. After the experiment, a dark brown molten residue remained in the sample container (original colour: off white). The change of the colour indicated reaction and/or decomposition of the test item. 

DSC EXPERIMENT 2

In order to investigate the melting peak, Experiment 2 was stopped directly after the melting peak.  The extrapolated onset temperature was 243.510°C. After the experiment, a white molten residue remained in the sample container. It demonstrated that melting was the reason for the endothermic effect.

DATA HANDLING

The melting temperature was determined as the mean extrapolated onset temperature of Experiment 1 and Experiment 2.

Conclusions:
The melting temperature of the substance was determined to be 243.5°C.

Executive summary:

Differential Scanning Calorimetry (DSC) experiments were performed in a GLP study according to EC A.1, OECD 102 and OPPTS 830.7200.

The melting temperature of the substance was determined in duplicate obtaining a mean value of 243.5°C. Reaction and/or decomposition of the substance started at 300°C.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion