Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Aquatic toxicity endpoints are based on test data following standard guidelines. All data are therefore considered to be reliable and relevant for the endpoint concerned.

 

Short-term toxicity to aquatic invertebrates

In acute ecotoxicity studies with Daphnia magna, Diurea 8 and Tetraurea 2 (in base grease) had 48-Hour EL50 (effective loading rate) values of greater than 100 mg/L WAF. The No Observed Effect Loading Rate (NOELR) for both Diurea 8 and Tetraurea 2 was 100 mg/L WAF.

The toxicity of Reaction product of m-tolylidene diisocyanate and cyclohexylamine and cyclohex-1,2-ylenediamine and (Z)-octadec-9-enylamine (in isolated form) toDaphnia magnawas investigated in an OECD guideline 202 study and the 48-hour EC50, based on nominal concentrations, was determined to be > 100 mg/L, the only concentration tested. The 48-hour NOEC was determined to be ≥ 100 mg/L.

Based on study results for category members, no toxicity to aquatic invertebrates is expected at the limit of solubility for substances within the TDI-I category. 

 

Toxicity to aquatic algae and cyanobacteria

The effects of two TDI-I category members on the growth of Pseudokirchneriella subcapitata were investigated in two separate studies (one conducted in base grease and one conducted on the isolated thickener). The studies followed OECD guideline 201 and used water accommodated fractions. Both studies demonstrated EL50 (effective loading rate) values of greater than 100 mg/L WAF. Correspondingly the No Observed Effect Loading Rates (NOELR) were 100 mg/L WAF.

One study conducted with Diurea 8 in base grease did show effects at <100 mg/L, but this was considered to be due to impurities in the sample, and therefore the study was repeated on both the isolated substance and the substance in base grease. Both of these studies showed EL50 values >100 mg/L WAF and NOELR values of 100 mg/L WAF. The first study is therefore disregarded due to impurities in the test sample. 

Based on the available data for category members, TDI-I substances are not considered to be toxic to algae at the limit of solubility. 

Additional information