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Density

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Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
22 September 2009
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.3 (Relative Density)
Version / remarks:
ECC Publication No. L383, December 1992
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Version / remarks:
Adopted July 1995
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)
Version / remarks:
June 2002
Deviations:
no
GLP compliance:
yes (incl. certificate)
Other quality assurance:
other: Chemikaliengesetz ('Chemicals Act') der Bundesrepublik Deutschland (ChemG), Anhang 1 ('Annex 1'), 2008 and Directive 2004/10/EC of 11 February 2004 (Official Journal No. L 50/44)
Type of method:
pycnometer method
Dynamic viscosity of test material:
Not reported
Key result
Type:
relative density
Density:
1.068 g/cm³
Temp.:
20 °C
Remarks on result:
other: Mean of runs 1 - 6. Standard deviation: 0.001

The determination of the relative density was performed by three-fold measurements of two independent test samples.

Table 1: Determination of the Density of the test item

 Measurement  Temperature (°C)  Sample cell empty (g)  Sample cell filled (g)  Amount of test item  Pressure p11 (psi)  Pressure p21 (psi)  Sample Volume2 (cm3)  Density3 (g/cm3)
 20.9  4.117  11.8666  7.7496  16.046  5.660  7.270892  1.066
 2  20.9  4.117  11.8666  7.7496  16.095  5.675  7.257554  1.068
 3  21.2  4.117  11.8666  7.7496  16.146  5.692  7.251833  1.069
 mean4  1.068
 SD  0.002
 4  21.1  4.1167  12.1291  8.0124  16.149  5.739  7.517266  1.066
 5  20.9  4.1167  12.1291  8.0124  16.120  5.722  7.478787  1.071
 6  21  4.1167  12.1291  8.0124  16.106  5.720  7.495882  1.069

 mean4

 1.069

SD

 0.003

 mean5

 1.068

 SD

 0.001

1 pressure readings obtained after pressurising the sample cell filled with test item

2 3 see calculations included in any other information on materials and methods

4 mean of replicate measurements

5 mean of independent sample values

SD standard deviation

Conclusions:
The mean relative density of the test item was determined to be 1.068 (± 0.001) at 20 ± 1 °C using the gas pycnometer method.

Executive summary:

The relative density of the test item was determined in an EC A.3 method, OECD 109 and OPPTS 830.1770 guideline study using the gas comparison pycnometer method. The volume of the sample and reference cells was calculated using two calibration balls with a known volume as reference. The calibration procedure involved three separate measurements. The test procedure was repeated using different test item samples until a repeatability of < ± 0.02 g/cm3 was reached. The mean relative density of the test item was determined to be 1.068 (± 0.001) at 20 ± 1 °C.

The study is a GLP compliant guideline experimental study, fully adequate for assessment of this endpoint.

Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 March 2018 to 12 April 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.3 (Relative Density)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
pycnometer method
Type:
relative density
Density:
1.01 other: unitless
Temp.:
20 °C

Table 1: Results of relative density study

 Parameter  Replicate 1  Replicate 2
 w1  24.00717  25.01722
 w2  48.98355  49.72920
 w3  44.26941  45.06167
 w4  27.01838  28.03092
 w5  44.87773  45.67259
 W1  24.97638  24.71198
 W2  20.26224  20.04445
 W3  3.01121  3.01370
 W4  17.85935

 17.64167

 W5

2.40289

2.40278 

 

 

 

 ptl

 0.8096

 0.8095

 Mean ptl

0.8096

 Vs

2.968

 2.968

 Dt4

 1.01

 1.02

 Mean Dt4

 1.01

Where:

w1= weight of empty pycnometer (g)

w2= weight of pycnometer and water (g)

w3= weight of pycnometer and displacement liquid (g)

w4= weight of pycnometer and test item (g)

w5= weight of pycnometer, test item and displacement liquid (g)

W1 = Mass of water to fill pycnometer

W2 = Mass of displacement liquid to fill pycnometer

W3 = Mass of test item added to pycnometer

W4 = Mass of displacement liquid required to fill pycnometer containing W3g of test item

W5 = Mass of displacement liquid equivalent to W3g of test item

ptl= density of displacement liquid at temperature of determination (g/mL)

Dt4= relative density of test item at test temperature compared to water at 4°C

Conclusions:
The relative density of the test item was determined to be 1.01 at 20 °C.
Executive summary:

The relative density of the test item was determined in a study following OECD 109 and EC Method A.3 guidelines, using the pycnometer method. The relative density of the test item was determined to be 1.01 at 20 °C.

The study is a GLP compliant, guideline experimental study and is fully acceptable for assessment of this endpoint.

Description of key information

The relative density of the test item was determined was determined to be 1.01 to 1.07 at 20 ± 1 °C.

Key value for chemical safety assessment

Relative density at 20C:
1.068

Additional information

The relative density of the test item was determined in two studies, one following EC A.3 method, OECD 109 and OPPTS 830.1770, using the gas comparison pycnometer method (Fieseler 2009b) and one following EC A.3 method study and OECD 109, alos using the pycnometer method (Dunning 2018). The mean relative density of the test item was determined to be in the range 1.01 to 1.068 at 20 ± 1 °C (Dunning 2018 and Fieseler 200b).

The studies are both GLP compliant, guideline experimental studies and are fully adequate for assessment of this endpoint.