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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 Jun 2016 to 06 Jul 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
July 1995
Qualifier:
according to
Guideline:
other: Council Regulation (EC) No 440/2008, Official Journal of the European Union, L 142, 31, p. 1 - 739,
Version / remarks:
May 2008
Qualifier:
according to
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
Version / remarks:
August 1996
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
0.49
Temp.:
20 °C
pH:
>= 7.02 - <= 7.09
Conclusions:
The Log Pow of the test item is determined to be 0.49
Executive summary:

The 1-octanol / water partition coefficient (Pow) of the test item has been determined using the shake flask method to be: 3.10 (± 0.049); which corresponds to a log Pow of 0.49 at 20 °C.

Description of key information

Log Kow = 0.49 at 20 °C, OECD 107, GLP, flask method, Halarnakar 2017

Key value for chemical safety assessment

Log Kow (Log Pow):
0.49
at the temperature of:
20 °C

Additional information

The 1-octanol / water partition coefficient (Pow) of the test item has been determined using the shake flask method to be: 3.10 (± 0.049); which corresponds to a log Pow of 0.49 at 20 °C.