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Melting point / freezing point

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Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was carried out in a laboratory accredited under GLP, however the study itself was not subject to GLP audit. The study followed OECD TG 102 (1995) and Method A1 in Regulation (EC) No 440/2008 without deviations.
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Qualifier:
according to
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
GLP compliance:
no
Type of method:
other: differential scanning calorimetry (DSC)
Melting / freezing pt.:
164.3 °C
Atm. press.:
>= 100.9 - <= 101.4 kPa
Remarks on result:
other: Relative standard deviations: 0.13% (°C) from the four determinations performed.

Melting temperatures, determination 1 -4

Thermal event

Temperature

°C

K

Extrapolated Endotherm onset temperature 1

164.47

437.6

Extrapolated Endotherm onset temperature 2

164.44

437.6

Extrapolated Endotherm onset temperature 3

164.07

437.2

Extrapolated Endotherm onset temperature 4

164.13

437.3

Conclusions:
In a valid, reliable and conclusive study the melting temperature of the test item was determined to be 164.3 °C (437.4 K) at 100.9-101.4 kPa.
Executive summary:

The study was performed to determine the melting temperature of the test item according to OECD TG 102 (1995) and Method A1 in Regulation (EC) No 440/2008. The mean melting temperature of the test item was determined to be 164.3 °C (437.4 K), with a relative standard deviation of 0.13% (°C) from the four determinations performed. The atmospheric pressure was in the range from 100.9 to 101.4 kPa.

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was carried out in a laboratory accredited under GLP, however the study itself was not subject to GLP audit. The study followed OECD TG 102 (1995) and Method A1 in Regulation (EC) No 440/2008 without deviations.
Qualifier:
according to
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
GLP compliance:
no
Type of method:
other: differential scanning calorimetry (DSC)
Melting / freezing pt.:
> 127.4 - < 163.1 °C
Atm. press.:
> 99.3 - < 99.8 kPa
Remarks on result:
other: Relative standard deviations: 0.79% and 0.33% (°C) from the four determinations performed.

Approximate start and end of the test item melting temperature ranges, determination 1 -4

Thermal event

Temperature

°C

K

Extrapolated start and end temperatures run 1

127.37-163.01

400.5-436.2

Extrapolated start and end temperatures run 2

128.31-162.17

401.5-435.3

Extrapolated start and end temperatures run 3

128.69-163.07

401.8-436.2

Extrapolated start and end temperatures run 4

129.81-162.08

403.0-435.2

Conclusions:
In a valid, reliable and conclusive study the melting temperature of the test item was determined to be 127.4 to 163.1 °C (400.5 to 436.2 K) at 99.3 to 99.8 kPa.
Executive summary:

To determine the melting temperature of the test item a study was performed according to OECD TG 102 (1995) and Method A1 in Regulation (EC) No 440/2008. The overall melting temperature range of the test item was determined to be 127.4 to 163.1 °C (400.5 to 436.2 K), with relative standard deviations of 0.79% and 0.33% (°C) from the four determinations performed for the start and end temperatures respectively. The atmospheric pressure was in the range 99.3 to 99.8 kPa

Description of key information

163.4 °C, OECD 102, GLP, DSC, O'Connor 2015

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
164.3 °C

Additional information

In a valid, reliable and conclusive study the melting temperature of the test item was determined to be 164.3 °C at 100.9-101.4 kPa. In a supporting study, the melting temperature of the test item was determined to be 127.4 to 163.1 °C at 99.3 to 99.8 kPa.