Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Mg(2Na)IDHA is expected to be moderately absorbed after oral exposure, based on its high water solubility, negative logPow as well as absorption rates known for free IDHA and calcium. The substance is poorly available for inhalation since it is in a micro granulated form with particles above 100 µm, has a low vapour pressure, and is highly hydrophilic. Mg(2Na)IDHA is also not expected to be absorbed following dermal exposure into the stratum corneum and into the epidermis, due to its high water solubility. Concerning its distribution in the body Mg(2Na)IDHA, if absorbed, is expected to be distributed mainly in the intravasal compartment, due to its high water solubility, and may be also transported to the liver. The substance does not indicate a significant potential for accumulation. Mg(2Na)IDHA is not expected to be significantly metabolised but to be eliminated unchanged mainly via the feaces and small amount via the urine.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
50
Absorption rate - dermal (%):
10
Absorption rate - inhalation (%):
50

Additional information