Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Modelled data indicate a general lack of concern for aquatic hazard with this substance. The substance is not released into the environment and is used as a site-limited intermediate.

Data source

Reference
Reference Type:
other: modelled data
Title:
EPISUITE 4.1 Results for F-37
Author:
U.S. EPA
Year:
2018
Bibliographic source:
U.S. EPA
Report Date:
2018

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Modelled data using acceptable model.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Sampling and analysis

Analytical monitoring:
no

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
not specified
Water media type:
not specified
Total exposure duration:
48 h

Test conditions

Reference substance (positive control):
no

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
>= 379.384 - <= 944.092 mg/L
Nominal / measured:
not specified
Basis for effect:
not specified
Remarks:
modelled data
Remarks on result:
not measured/tested
Remarks:
modelled data
Details on results:
ECOSAR Program (v1.11) Results:
===============================
ECOSAR Version 1.11 Results Page
SMILES : CC(=O)CC(=O)N(CC(=O)OCC)c1ccccc1
CHEM : F-37
CAS Num:
ChemID1:
MOL FOR: C14 H17 N1 O4
MOL WT : 263.30
Log Kow: 0.866 (EPISuite Kowwin v1.68 Estimate)
Log Kow: (User Entered)
Log Kow: (PhysProp DB exp value - for comparison only)
Melt Pt: (User Entered for Wat Sol estimate)
Melt Pt: (deg C, PhysProp DB exp value for Wat Sol estimate)
Wat Sol: 3629 (mg/L, EPISuite WSKowwin v1.43 Estimate)
Wat Sol: (User Entered)
Wat Sol: (PhysProp DB exp value)
--------------------------------------
Values used to Generate ECOSAR Profile
--------------------------------------
Log Kow: 0.866 (EPISuite Kowwin v1.68 Estimate)
Wat Sol: 3629 (mg/L, EPISuite WSKowwin v1.43 Estimate)
--------------------------------------
ECOSAR v1.11 Class-specific Estimations
--------------------------------------
Esters
Amides
Predicted
ECOSAR Class Organism Duration End Pt mg/L (ppm)
=========================== ================== ======== ====== ==========
Esters : Daphnid 48-hr LC50 379.384
Amides : Daphnid 48-hr LC50 944.092

Applicant's summary and conclusion

Conclusions:
Using the ECOSAR v1.11 model the estimated LC50 values for this substance range from 379.384 to 944.092 mg/L.
Executive summary:

The ECOSAR results for daphnia are as follows:

ECOSAR Program (v1.11) Results:

===============================

ECOSAR Version 1.11 Results Page

SMILES : CC(=O)CC(=O)N(CC(=O)OCC)c1ccccc1

CHEM : F-37

CAS Num:

ChemID1:

MOL FOR: C14 H17 N1 O4

MOL WT : 263.30

Log Kow: 0.866 (EPISuite Kowwin v1.68 Estimate)

Log Kow: (User Entered)

Log Kow: (PhysProp DB exp value - for comparison only)

Melt Pt: (User Entered for Wat Sol estimate)

Melt Pt: (deg C, PhysProp DB exp value for Wat Sol estimate)

Wat Sol: 3629 (mg/L, EPISuite WSKowwin v1.43 Estimate)

Wat Sol: (User Entered)

Wat Sol: (PhysProp DB exp value)

--------------------------------------

Values used to Generate ECOSAR Profile

--------------------------------------

Log Kow: 0.866 (EPISuite Kowwin v1.68 Estimate)

Wat Sol: 3629 (mg/L, EPISuite WSKowwin v1.43 Estimate)

--------------------------------------

ECOSAR v1.11 Class-specific Estimations

--------------------------------------

Esters

Amides

Predicted

ECOSAR Class Organism Duration End Pt mg/L (ppm)

=========================== ================== ======== ====== ==========

Esters : Daphnid 48-hr LC50 379.384

Amides : Daphnid 48-hr LC50 944.092