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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1977
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
2.01; 2.41; 2.89; 3.47 or 4.17mL / kg bw
No. of animals per sex per dose:
3
Control animals:
yes

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2.22 mL/kg bw
Based on:
test mat.
95% CL:
2.03 - 2.44
Mortality:
Death ocurred between 3h and 7 days after dosing.
Clinical signs:
Rats shiwed sluggishness and humpback behaviour. Some of the rats lost consiousness. Within 24 hours after treatment green.coloured urine was observed in all dose groups.
After 24 hours all rats showed urine stains on the fur of the abdominal region. They produced red coloured urine.
Body weight:
Males: 122 - 236 g
Females: 95-195 g

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The material can be classified as slightly toxic.