Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
not specified
Preparation of test site:
other: intacted and abraded
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
not specified
Duration of treatment / exposure:
scintillated
Observation period:
24 and 72 h
Number of animals:
6 intacted skin group and 6 abraded skin group

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
3.7
Max. score:
4
Reversibility:
not specified
Remarks on result:
other: intact skin
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
72 h
Score:
1.3
Max. score:
2
Reversibility:
not specified
Remarks on result:
other: intact skin
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
4.2
Max. score:
4
Reversibility:
not specified
Remarks on result:
other: abraded skin
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
72 h
Score:
1.5
Max. score:
2
Reversibility:
not specified
Remarks on result:
other: abraded skin

Applicant's summary and conclusion

Interpretation of results:
Category 3 (mild irritant) based on GHS criteria