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Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1977
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes
Species:
rat
Strain:
Wistar
Sex:
male/female
Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
2.01; 2.41; 2.89; 3.47 or 4.17mL / kg bw
No. of animals per sex per dose:
3
Control animals:
yes
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2.22 mL/kg bw
Based on:
test mat.
95% CL:
2.03 - 2.44
Mortality:
Death ocurred between 3h and 7 days after dosing.
Clinical signs:
Rats shiwed sluggishness and humpback behaviour. Some of the rats lost consiousness. Within 24 hours after treatment green.coloured urine was observed in all dose groups.
After 24 hours all rats showed urine stains on the fur of the abdominal region. They produced red coloured urine.
Body weight:
Males: 122 - 236 g
Females: 95-195 g
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The material can be classified as slightly toxic.
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1978
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
yes
Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals and environmental conditions:
Yound adults albino rats (wistar derived) from the INstitute's colony were used. The body weight of males varied from 170 to 262g and those for females from 95 to 170g. The rats were housed in groups of three, in screened-bottomed, stainless steel, cages in a well-ventilated room maintained at 23-25°C
Route of administration:
oral: gavage
Vehicle:
propylene glycol
Doses:
4; 6; 9; 13.4 and 20.3 mL
No. of animals per sex per dose:
3
Control animals:
not specified
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1.68 mg/kg bw
Based on:
test mat.
95% CL:
1.34 - 2.11
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The material can be classified as slightly toxic.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50

Additional information

Justification for classification or non-classification

The material can be classified as slightly toxic.