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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018-03-16 to 2018-04-18
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Specific details on test material used for the study:
Name: tert-Butyl glycidyl ether
CAS No.: 7665-72-7
Batch No.: ZMG-195668
Appearance: Clear colourless liquid
Molecular formula: C7H14O2
Content: 99.8% (area)
Storage conditions: Cool, protected from light
Expiry date: 07 March 2019
Key result
Water solubility:
90.3 g/L
Incubation duration:
>= 24 - <= 72 h
Temp.:
20 °C
pH:
6.4

Check of the temperature

The measured temperatures at the pre-incubation and the thermostatisation phase are summarized in Table 1. The additional manual values confirm the values of the data logger.

Table 1: Temperature at pre-incubation (30 °C) and thermostatisation phase (20 °C) (measured hourly)

Intended temperature

[°C]

Measured temperature

[°C]

min.

max.

Mean value ± SD

30.0 ± 0.5

29.93

30.11

30.02 ± 0.04

20.0 ± 0.5

20.02

20.38

20.09 ± 0.07

Check of pH-value

The pH-values were determined with the remaining test item mixtures in the original test vessels which were kept constant at 20 ± 0.5 °C. pH-values of the test mixtures are summarized in Table 2.

Table 2: pH-value of the test mixture for double distilled water

Test temperature [°C]

Pre‑incubation time [h]

Replicate


Measured
pH

 

Mean value

 

20

24

1

6.331

6.4

2

6.444

48

1

6.399

2

6.409

72

1

6.598

2

6.472

Control

6.151

Check of Tyndall-effect

No Tyndall-effect was observed for any of the centrifuged samples.

Water solubility results

No significant signals were obtained for the control sample. The water solubility results of the test item are summarized in Table 3.

Table 3: Water solubility results at 20 °C for tert-Butyl glycidyl ether

Pre-incubation time

Replicate

tert‑Butyl glycidyl ether
[g/L]

Concentration*

Mean

24 h

1

90.5

90.6

2

90.7

48 h

1

90.2

90.1

2

90.1

72 h

1

90.1

90.1

2

90.1

Mean (24 - 72 h)

 

 

90.3

Deviation [%] (24 - 72 h)

0.6

* mean value of two injections, dilution factor of 10 and exact weight of the standard taken into account

Validity criteria

The validity criteria were fulfilled:

- The concentration measured at each sampling time did not differ for more than 15%

- Temperatures were kept constanct within ± 0.5 °C.

Conclusions:
The water solubility of the test item at 20 °C was 90.3 g/L (pH 6.4).
Executive summary:

The water solubility of the test item was determined according to OECD test guideline 105 using the flask method. The mean water solubility for three pre-incubation times 24 h, 48 h and 72 h was 90.3 g/L and a mean pH of 6.4 was observed. The validity criteria were fulfilled.

Description of key information

The water solubility of the test item was determined according to OECD test guideline 105 using the flask method. The mean water solubility for three pre-incubation times 24 h, 48 h and 72 h was 90.3 g/L and a mean pH of 6.4 was observed. The validity criteria were fulfilled.

Key value for chemical safety assessment

Water solubility:
90.3 g/L
at the temperature of:
20 °C

Additional information