Registration Dossier
Registration Dossier
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EC number: 219-868-9 | CAS number: 2556-10-7
Carcinogenicity
Administrative data
Description of key information
The genotoxicity of the substance has been assessed in vitro for three genotoxicity endpoints: genotoxicity in bacteria (read across with Hyacinth body #3, and supporting results obtained with Hyacinth body), in vitro micronucleus and gene mutation test in mammalian cells, resulting in the absence of genotoxicity. Hyacinth body is considered negative for genotoxicity and therefore is not considered a genotoxic carcinogen.
Key value for chemical safety assessment
Justification for classification or non-classification
The genotoxicity of the substance has been assessed in vitro for three genotoxicity endpoints: genotoxicity in bacteria (read across with Hyacinth body #3, and supporting results obtained with Hyacinth body), in vitro micronucleus and gene mutation test in mammalian cells, resulting in the absence of genotoxicity.
Therefore, no genotoxic carcinogenicity is expected, via the oral, inhalation and dermal route. The substance does not have to be classified for genotoxic carcinogenicity in accordance with EU CLP (EC No. 1272/2008 and its amendments).
Additional information
In accordance with Annex VIII information, carcinogenicity is not required for a substance manufactured/imported in amounts 10-100 tons. The substance has shown to be not genotoxic in vitro in the Ames, in vitro micronucleus and gene mutation test in mammalian cells. Therefore, no genotoxic carcinogenicity is expected, via the oral, inhalation and dermal route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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