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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials: d-Carvone
Author:
D. L. J. Opdyke
Year:
1978
Bibliographic source:
Food and Cosmetics Toxicology,Vol. 16, Pg. 673, 1978.
Reference Type:
other: authoritative database
Title:
Acute dermal toxicity study of d-Carvone (2244-16-8) in rabbits
Author:
U.S. National Library of Medicine
Year:
2017
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2017
Reference Type:
secondary source
Title:
Acute dermal toxicity study of d-Carvone (2244-16-8) in rabbits
Author:
RTECS
Year:
2017
Bibliographic source:
RTECS (registry of toxic effect of chemical substance data base ), 2017

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute dermal toxicity test was carried out to study the effects of d-Carvone (2244-16-8) on rabbits.
GLP compliance:
not specified
Test type:
other: no data available
Limit test:
no

Test material

Reference
Name:
Unnamed
Details on test material:
- Name of test material (IUPAC name): (5S)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one- Common name: d-Carvone- Molecular formula: C10H14O- Molecular weight: 150.22 g/mol- Smiles notation: C1[C@H](CC=C(C1=O)C)C(C)=C- InChl: 1S/C10H14O/c1-7(2)9-5-4-8(3)10(11)6-9/h4,9H,1,5-6H2,2-3H3/t9-/m0/s1- Substance type: Organic
Specific details on test material used for the study:
- Name of test material (as cited in study report):d-Carvone- Molecular formula :C10H14O- Molecular weight :150.22 g/mol- Substance type:organic

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Type of coverage:
other: dermal
Vehicle:
not specified
Details on dermal exposure:
No data available
Duration of exposure:
No data available
Doses:
4000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
- Other examinations performed: clinical signs
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 000 mg/kg bw
Remarks on result:
other: 50% mortality was observed at dose 4000 mg/kg bw in treated rabbits
Mortality:
50% mortality was observed at dose 4000 mg/kg bw in treated rabbits
Clinical signs:
After systemic exposure,Skin dermatitis and changes in appendages were observed
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The lethal concentration (LD50) value for acute dermal toxicity test was considered to be 4000 mg/kg bw,when rabbits were treated with d-Carvone (2244-16-8) orally.
Executive summary:

In acute dermal toxicity study,rabbits were treated with d-Carvone(2244-16-8)in the concentration of 4000 mg/kg bw by dermal application.50% mortality was observed at dose 4000 mg/kg bw in treated rabbits.After systemic exposure,Skin dermatitis and changes in appendages were observed.Therefore, LD50 value was considered to be 4000 mg/kg bw,when rabbits were treated with d-Carvone (2244-16-8)by dermal application.