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EC number: 218-827-2
CAS number: 2244-16-8
In acute inhalation toxicity study, rats were exposed to 2-Methyl-5-(1-methylethenyl)-2-cyclohexenone(99-49-0)in the concentration of 5.66 mg/l in air (5660 mg/m3) inhaled as a Single dose. One female died the day after the exposure. During exposure a decreased breathing frequency, and less frequently, post-inspiratory apnoea and superficial breathing were observed. After exposure and increased breathing frequency, post-inspiratory apnoea and dyspnoea were seen. Clinical signs during exposure were restlessness and stress and in coordination and tremors. A dirty and wet fur was observed 24-48h after treatment. Alopecia was observed in a few rats at days 7-13. Body weight gain was impaired in most rats during the first week after treatment. Normal body weight gain was observed in the second week, except for two females that showed only marginal body weight gain.GrossPathology revealed no abnormalities, except in the female that died the day after exposure: dark foamy lungs, light coloured liver and air-filled stomach and intestines were observed.
Therefore, LC50 value was considered to be >5.66 mg/l in air (5660 mg/m3), when rats were exposed with 2-Methyl-5-(1-methylethenyl)-2-cyclohexenone (99-49-0) by inhalation according to OECD Guideline 403 (Acute Inhalation Toxicity).
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