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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
February 23 to 24, 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately characterised. Therefore full validation applies.
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Council Regulation (EC) No 761/2009 of 23 July 2009
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
inspected on 13 and 14 October 2014 / signed on 08 April 2015
Type of method:
static method
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
471 Pa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
699 Pa

Table 4.6/1: Measurement Values

 

1. Determination

increasing temperature

2. Determination

decreasing temperature

Temp. in °C

Pressure in hPa

Temp. in °C

Pressure in hPa

20.0

5.2

45.8

31.40

28.2

8.9

36.2

15.80

37.1

16.8

29.9

9.80

46.1

32.1

22.7

5.50

53.4

55.9

15.5

3.30

The calculation results are presented in the following table:

Table 4.6/2: Calculated values for 1/T and log P

 

n                  

Temperature T (°C)

Pressure P (hPa)

Temperature T (K)

1/T (1/K)

log P

log Pa

1

20.0

5.2

293.15

0.00341122

2.7160

2

28.2

8.9

301.35

0.00331840

2.9494

3

37.1

16.8

310.25

0.00322321

3.2253

4

46.1

32.1

319.25

0.00313234

3.5065

5

53.4

55.9

326.55

0.00306232

3.7474

6

45.8

31.4

318.95

0.00313529

3.4969

7

36.2

15.8

309.35

0.00323258

3.1987

8

29.9

9.8

303.05

0.00329979

2.9912

9

22.7

5.5

295.85

0.00338009

2.7404

10

15.5

3.3

288.65

0.00346440

2.5185

 

linear regression :

y = -3001.559361 x + 12.9120164

r = -0.99863974

r² = 0.997 (> 0.95)

Using the equations below, vapour pressures at ambient temperature were calculated.

P(20 °C) = 10B * (1/293.15) + A 

P(25 °C) = 10B * (1/298.15) + A

Table 4.6/3: Calculated Values for vapour pressure

Parameter

Value

Vapour Pressure (20 °C)

471 Pa

Vapour Pressure (25 °C)

699 Pa

 

The vapour pressure of the test item was measured using the static method as described in EU method A.4. Ten pairs temperature/vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature could be estimated. From the measured values, the vapour pressure of the test item was calculated as 471 Pa at 20.0 °C and 699 Pa at 25 °C. The values of the heating and cooling down phase showed good correspondence. Therefore, the result of the study is considered valid.

Conclusions:
The vapour pressure of the test item was calculated as 471 Pa at 20.0 °C and 699 Pa at 25 °C (interpolation).
These values represent the components with the highest vapour pressure.
Executive summary:

The vapour pressure of test item was measured using the static method as described in EU method A.4 and OECD 104. Ten pairs temperature/vapour pressure were used to calculate a regression in a temperature range of 15.5 – 53.4 °C, from which vapour pressure at ambient temperature could be estimated.

From the measured values, the vapour pressure of the test item was calculated as 471 Pa at 20 °C and 699 Pa at 25 °C.

These values represent the components with the highest vapour pressure.

Description of key information

The vapour pressure of the test item was determined as 471 Pa at 20.0 °C and 699 Pa at 25 °C (interpolation).

These values represent the components with the highest vapour pressure.

Key value for chemical safety assessment

Vapour pressure:
699 Pa
at the temperature of:
25 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study, and the result can be retained as key data for purpose of CSA.

Note that the result obtained on this kind of substance should be largely influence by small amounts of volatile constituents and these values don't represent the major part of the substance. Therefore the result should be considered with caution when used for subsequent assessment (worst case).