Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

No data are available on the toxicokinetic properties of the registered substance. It is a complex mixture, which contains a large number of unknown constituents but which have different solubilities (often low solubility) and volatilities. In addition the physical state of such complex substance is described as a dark brown viscous and extremely sticky paste like, solid at room temperature and atmospheric pressure. It is difficult to estimate the toxicokinetic properties of the substance based on its physico-chemical properties because no information is available on the water solubility, partition coefficient and volatility of the whole substance and information on a very limited part of the constituents is available. In the in vitro micronucleus test, lower cytotoxicity was observed in presence of metabolic activation which may indicate metabolisation of the substance into less cytotoxic metabolites. More hypotheses on the toxicokinetic behaviour of the substance can be inferred from the repeated dose toxicity data of the on-going OECD TG 422 study, once available.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
100
Absorption rate - inhalation (%):
100

Additional information

No data are available on the toxicokinetic properties of the registered substance. It is a complex mixture, which contains a large number of unknown constituents but which have different solubilities (often low solubility) and volatilities. In addition the physical state of such complex substance is described as a dark brown viscous and extremely sticky paste like, solid at room temperature and atmospheric pressure. It is difficult to estimate the toxicokinetic properties of the substance based on its physico-chemical properties because no information is available on the water solubility, partition coefficient and volatility of the whole substance and information on a very limited part of the constituents is available. In the in vitro micronucleus test, lower cytotoxicity was observed in presence of metabolic activation which may indicate metabolisation of the substance into less cytotoxic metabolites. More hypotheses on the toxicokinetic behaviour of the substance can be inferred from the repeated dose toxicity data of the on-going OECD TG 422 study, once available.