1,1'-(1-phenylethane-1,1-diyl)bis[4-(heptyloxy)benzene]

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

14 June 2016 to 12 July 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Version / remarks:

Deviations from the maximum level of daily mean relative humidity occurred. The study integrity was not adversely affected by the deviation.

Deviations:

yes

Remarks:

Deviations from the maximum level of daily mean relative humidity occurred. The study integrity was not adversely affected by the deviation.

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,1'-(1-phenylethane-1,1-diyl)bis[4-(heptyloxy)benzene]

EC Number:

811-683-7

Cas Number:

1799707-26-8

Molecular formula:

C34H46O2

IUPAC Name:

1,1'-(1-phenylethane-1,1-diyl)bis[4-(heptyloxy)benzene]

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

Three animals

Control animals:

not specified

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

No mortality occurred.

Clinical signs:

No clinical signs were noted.

Body weight:

The mean body weight gain shown by the animals over the study period was considered to be normal.

Gross pathology:

No abnormalities were found at macroscopic post mortem examination of the animals.

Other findings:

No findings noted.

Applicant's summary and conclusion

Interpretation of results:

other: EU classification criteria not met

Conclusions:

The oral LD50 of the sunstance in Wistar rats was established to exceed 2000 mg/kg body weight.

Executive summary:

In an acute toxicity study the substance was administered to Wistar rats (3 animals/sex/dose) by oral gavage at a dose level of 2000 mg/kg bw (single administration). There were no mortalities or signs of clinical toxicity, mean body weight gain was comparable with the control animals and no abnormalities found at macroscopic post-mortem examination. The LD50 is 2000 mg/kg bw.