Registration Dossier
Registration Dossier
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EC number: 221-698-5 | CAS number: 3195-78-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Four rabbits were exposed to the test item for 24 hours by an occlusive clip. The observation period was 14 days.
- GLP compliance:
- no
- Remarks:
- study performed prior to implementation of GLP
- Test type:
- other: Please refer to principles of method if other than guideline
Test material
- Reference substance name:
- N-methyl-N-vinylacetamide
- EC Number:
- 221-698-5
- EC Name:
- N-methyl-N-vinylacetamide
- Cas Number:
- 3195-78-6
- Molecular formula:
- C5H9NO
- IUPAC Name:
- N-ethenyl-N-methylacetamide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Weight: 2.5 to 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- - Fur is removed by clipping
- Dose is retained beneath an impervious plastic film
- The animals are immobilized during the 24-hour contact period - Duration of exposure:
- 24 hour followed by a 14-day observation period
- Doses:
- no data
- No. of animals per sex per dose:
- four
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1.41 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: corresponding to 1354 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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