Registration Dossier
Registration Dossier
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EC number: 259-583-7 | CAS number: 55302-96-0
Endpoint summary
Administrative data
Description of key information
Skin sensitisation:
The murine Local Lymph Node Assay (LLNA) key study (OECD Guideline 429, GLP, Klimisch 1) showed that 2-methyl-5-hydroxyethylamino-phenol did not induce delayed contact hypersensitivity.
Respiratory sensitisation:
No study available.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Only one study is available for the skin sensitisation endpoint (in vivo study). This key study (OECD guideline 429, GLP, Klimisch 1), in which female mice were exposed to 2-methyl-5-hydroxyethylamino-phenol at the concentrations of 2.5, 5, 10, 25 and 50% (w/v) in the vehicle (dimethylformamide), showed no cutaneous reactions and increases in ear thickness in the treated animals, and no lymphoproliferative responses in the test substance groups, while lymphoproliferation was observed with the positive control group [alpha-hexylcinnamaldehyde at 25% (SI value of 8.39)]. This study showed that 2-methyl-5-hydroxyethylamino-phenol did not induce delayed contact hypersensitivity in a murine Local Lymph Node Assay (LLNA).
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Skin sensitisation:
Based on the available key data, 2-methyl-5-hydroxyethylamino-phenol does not require a classification for skin sensitisation according to the Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) and the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) criteria.
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