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EC number: 259-583-7 | CAS number: 55302-96-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation / corrosion: 2-Methyl-5-hydroxyethylamino-phenol is not irritant to rabbit skin when tested undiluted (OECD Guideline 404, GLP, Klimisch 1)
Eye irritation: 2-Methyl-5-hydroxyethylamino-phenol is irritant to rabbit eye when tested undiluted (OECD Guideline 405, GLP, Klimisch 1)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / corrosion:
Only one study is available for the skin irritation / corrosion endpoint (in vivo study). This key study (OECD guideline 404, GLP, Klimisch 1), in which New Zealand White rabbits were administred undiluted 2-Methyl-5-hydroxyethylaminophenol during 4 hours under semiocclusive dressing, showed no dermal lesions in any animal at any of the observation time points (24, 48 and 72 hours). The individual mean scores (24, 48 and 72 hours) of all three animals for erythema and edema were both: 0.0, 0.0 and 0.0. This study showed that when tested undiluted, 2-methyl-5-hydroxyethylaminophenol was non-irritant to rabbit skin.
Eye irritation:
Two in vivo studies are available for the eye irritation endpoint (one key and one supporting). The key study (OECD guideline 405, GLP, Klimisch 1), in which New Zealand White rabbit eyes were instilled undiluted 2-Methyl-5-hydroxyethylaminophenol without rinsing, showed slight swelling and slight redness of conjunctivae 1 hour after administration. At 24 and 48 hours, animals showed significant swelling with eyelids half or completely closed. At 72 hours, a marked decrease in chemosis was observed. At 24 through 72 hours, significant redness was noted. Grading of the iris was not possible resulting from corneal
opacity. From 1 hour after instillation, corneal translucency was easily identifiable. The cumulative mean indices of chemosis, redness, and cornea were 3.33, 2.00, and 2.33, respectively. This study showed that 2-methyl-5-hydroxyethylaminophenol is an irritant to rabbit eyes when tested undiluted. The supporting study (OECD guideline 405, GLP, Klimisch 1), in which New Zealand White rabbit eyes were instilled 2-Methyl-5-hydroxyethylaminophenol at a concentration of 2% (diluted in a 0.5% carboxymethylcellulose suspension) without rinsing, showed no ocular reactions for any of the three animals treated. This supporting study, showed that a 2% dilution of 2-Methyl-5-hydroxyethylaminophenol was non-irritating to rabbit eyes.
Justification for classification or non-classification
Skin irritation / corrosion:
Based on the available key data, 2-Methyl-5-hydroxyethylaminophenol does not require classification for skin irritation according to the Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) and the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) criteria.
Eye irritation:
Based on the available key data, 2-Methyl-5-hydroxyethylaminophenol requires a classification for eye irritation as Eye Irritant Category 2 (Eye Irrit. 2, H319) according to the Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) and the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) criteria.
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