Registration Dossier
Registration Dossier
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EC number: 204-516-9 | CAS number: 122-03-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 979
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Mutagenicity screening using the Salmonella / microsome assay of Ames and the Salmonella typhimurium strains TA100 and TA98
- GLP compliance:
- no
- Type of assay:
- other: Mutagenicity screening
Test material
- Reference substance name:
- 4-isopropylbenzaldehyde
- EC Number:
- 204-516-9
- EC Name:
- 4-isopropylbenzaldehyde
- Cas Number:
- 122-03-2
- Molecular formula:
- C10H12O
- IUPAC Name:
- 4-(propan-2-yl)benzaldehyde
- Test material form:
- liquid
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 98
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 100
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with
- Metabolic activation system:
- S9
Controls
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- no
- True negative controls:
- no
- Positive controls:
- yes
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not applicable
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not applicable
- Untreated negative controls validity:
- not applicable
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Conclusions:
- Negative for TA98 and TA100 in the absence and presence of S9.
- Executive summary:
Based on the results in this study, Cuminic Aldehyde was not mutagenic in the strains TA100 and TA98.
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