Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1997
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
PREDICTING MODES OF TOXIC ACTION FROM CHEMICAL STRUCTURE: ACUTE TOXICITY IN THE FATHEAD MINNOW (PIMEPHALES PROMELAS)
Author:
CHRISTINE L. RUSSOM, STEVEN P. BRADBURY, STEVEN J. BRODERIUS,
DEAN E. HAMMERMEISTER and ROBERT A. DRUMMOND
Year:
1997
Bibliographic source:
Environmental Toxicology and Chemistry, Vol. 16, No. 5, pp. 948–967

Materials and methods

Test guideline
Guideline:
other:
Version / remarks:
Database for 96-h LC50 values for the fathead minnow, established by US EPA, national Health and Environmental Effects Research laboratory, Duluth, Minnesota. Contains values for approximately 600 chemicals.
Principles of method if other than guideline:
The chemical set chosen for study was based on an assessment of the U.S. industrial chemical inventory of discrete organic chemicals.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
Chemical cited as p-isopropyl benzaldehyde, CAS 122-03-2, log P = 3.07.

Log of the octanol : water partition coefficient estimated using CLOGPTM program version 3.4 within the UDRIVE system version 3.53, 1988, from Pomona College Medicinal Chemistry
Project, Claremont, CA, USA.

Test organisms

Test organisms (species):
Pimephales promelas

Results and discussion

Effect concentrations
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
6.62 mg/L
Details on results:
Experimental data in ECOSAR training set (Reference DUL) and OECD toolbox v3.4.0.17.
Original reference (Russom et al, 1997) cited in https://www.epa.gov/sites/production/files/2015-09/documents/ecosartechfinal.pdf and OECD toolbox.

Applicant's summary and conclusion

Conclusions:
A published experimental 96h LC50 value of 6.6mg/L is available.