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EC number: 946-382-0
CAS number: -
In an oral toxicity study performed in general conformance with OECD
guideline 401, PEMP was dosed to male and female rats (5/ sex/ dose) at
350, 500, 700, 1000 and 1400 mg/kg bw. No males died up to 700 mg/kg bw,
one female died at 700 mg/kg bw. At 1000 mg/kg bw, 2/5 males died and
3/5 females and at 1400 mg/kg bw, 4/5 males and all females died. All
rats died within 24 hours of dosing. Several clinical signs were noted,
including nasal and oral discharge, fecal staining, abdominal griping
and hypoactivity at the day of dosing. The number of animals affected
was dose-related. Additionally, for some animals convulsions, hyperpnea,
ocular discharge and urinary staining were observed. Several animals had
decreased food intake on the day of dosing (for one female dosed at 1000
mg/kg bw, this continued until day 9). At necropsy, substance-related
changes in the lungs at 700 mg/kg bw and above were seen (discoloration
and/or red foci in the lung). Furthermore, abnormalities in the
gastrointestinal tract were found. In animals exposed to 1000 or 1400
mg/kg bw that were found dead, a yellow fluid was found in the
intestines. One male in the group dosed at 1400 mg/kg bw had red fluid
in the intestine. Another male in this group had a thickened stomach
wall, and a female at this dose had yellow fluid in the stomach.
Based on these data, the oral LD50 for PEMP was determined to be 908
mg/kg bw, the substance is classified for oral toxicity in category 4
according to Regulation (EC) 1272/2008.
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