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EC number: 223-296-5 | CAS number: 3811-73-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.007 mg/L
Additional information
See Tables 6.1.1.1, 6.1.1.2, 6.1.1.3, and 6.1.1.4 for summaries on the acute toxicity to fish of sodium pyrithione and its metabolites.
The acute studies on fish indicate that NaPT is toxic to fish. The LC50values range from 0.0066 to 1.3 mg NaPT/L with Onchorynchus mykiss (rainbow trout) being the most sensitive species. The NOEC for this study was 0.0026 mg NaPT/L.
Further, acute toxicity studies in fish for the major metabolites indicate that the most toxic substance is Pyrithione disulphide with a NOEC of 0.011 mg/L, to the freshwater species Pimephales promelas (Fathead Minnow), but that this is many times less toxic than the parent compound Sodium Pyrithione. However, Pyrithione disulphide is very short lived in the environment (photolytic half-life is 2.5 minutes) and the most relevant degradant of NaPT is Pyridine sulphonic acid (PSA). The NOEC for PSA is 46.9 mg/L for the rainbow trout.
Table 6.1.1.1: Acute toxicity of NaPT to fish
Guideline / |
Species |
End-point / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
design |
duration |
NOEC |
LC50 |
LC100 |
|
||||
US EPA-540/9-85-006 |
Freshwater Rainbow trout
Oncorhyncus mykiss
|
Mortality |
Flow-through |
96 hours |
1.000 |
1.300 |
>1.300 |
|
6.1.1.001 ESPTF 7041-101 Croudace et al (1996) |
U.S. EPA-FIFRA, Guideline 72-1 (comparableto OECD 203) |
Freshwater Rainbow trout
Oncorhyncus mykiss
|
Mortality |
Flow-through |
96 hours |
0.0026 |
0.0066 |
0.011 |
|
Key Study
6.1.1.002 ESPTF 7041-102 O’Boyle et al (1988) |
U.S. EPA-FIFRA, Guideline 72-1 (comparableto OECD 203) |
Bluegill sunfish (Lepomis Machrochirus).
|
Mortality |
Flow-through |
96 hours |
0.88 |
9.6 |
n.a. |
|
6.1.1.003 ESPTF 7041-103 Ewell et al (1987) |
Table 6.1.1.2: Acute toxicity of Pyridine-N-oxide-2-sulfonic acid to fish
Guideline / |
Species |
End-point / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
design |
duration |
NOEC |
LC50 |
LC100 |
|
||||
US EPA- 72-1 |
Freshwater Fathead Minnow
Pimephales promelas
|
Mortality
|
Flow-through |
96 hours |
48.7 |
58.8 |
|
Key study |
6.1.1.009 EZPTF 7041-117 Ward TJ, Kowalski PL, Boeri RL (1994) |
US EPA- 72-1 |
Freshwater Rainbow trout
Oncorhyncus mykiss
|
Mortality
|
Flow-through |
96 hours |
73.6 |
92.3 |
|
|
6.1.1.005 EZPTF 7041-111 Ward TJ, Kowalski PL, Boeri RL (1994) |
US EPA- 72-3 (b) |
Marine Sheepshead Minnow
Cyprinodon variegatus |
Mortality
|
Flow-through |
96 hours |
137 |
>137 |
6.1.1.007 EZPTF 7041-114 Boeri RL, Kowalski PL, Ward TJ (1994) |
Table 6.1.1.3: Acute toxicity of Pyridine sulphonic acid to fish
Guideline / |
Species |
End-point / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
design |
duration |
NOEC |
LC50 |
LC100 |
|
||||
US EPA- 72-1 |
Freshwater Fathead Minnow
Pimephales promelas
|
Mortality
|
Flow-through |
96 hours |
55.2 |
68.5 |
6.1.1.010 EZPTF 7041-118 Boeri RL, Kowalski PL, Ward TJ (1994) |
||
US EPA- 72-1 |
Freshwater Rainbow trout
Oncorhyncus mykiss
|
Mortality
|
Flow-through |
96 hours |
46.9 |
57.1 |
|
|
6.1.1.006 EZPTF 7041-112 Ward TJ, Kowalski PL, Boeri RL (1993) |
US EPA- 72-3 (b) |
Marine Sheepshead Minnow
Cyprinodon variegatus |
Mortality
|
Flow-through |
96 hours |
127 |
>127 |
6.1.1.008 EZPTF 7041-115 Boeri RL, Kowalski PL, Ward TJ (1994) |
Table 6.1.1.4: Acute toxicity of 2,2’-(pyridyl-N-oxide) disulphide to fish
Guideline / |
Species |
End-point / |
Exposure |
Results [mg/L] |
Remarks |
Reference |
|||
design |
duration |
NOEC |
LC50 |
LC100 |
|
||||
US EPA- 72-1 |
Freshwater Fathead Minnow
Pimephales promelas
|
Mortality
|
Flow-through |
96 hours |
0.011 |
0.030 |
6.1.1.004 EZPTF 7041-116 Ward TJ, Magazu JP, Boeri RL (1995) |
||
US EPA- 72-1 |
Freshwater Rainbow trout
Oncorhyncus mykiss
|
Mortality
|
Flow-through |
96 hours |
0.018 |
0.054 |
6.1.1.011 EZPTF 7041-110 Ward TJ, Magazu JP, Boeri RL (1995) |
||
US EPA- 72-3 (b) |
Marine Sheepshead Minnow
Cyprinodon variegatus |
Mortality
|
Flow-through |
96 hours |
<0.52 |
1.1 |
6.1.1.012 EZPTF 7041-113 Ward TJ, Magazu JP, Boeri RL (1995) |
The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under RegulationEC 1907/2006.
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