Registration Dossier
Registration Dossier
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EC number: 202-430-6 | CAS number: 95-54-5
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- Secondary source reviewed, original document not reviewed.
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Galushka, A. I. et al.
- Year:
- 1 985
- Bibliographic source:
- Gig. Sanit., 6:78-79 (cited in the American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, p. 1214, II, III. Cincinnati, OH: ACGIH, 1991).
Materials and methods
Test guideline
- Guideline:
- other: no guideline reported in secondary source
- GLP compliance:
- no
Test material
- Reference substance name:
- o-phenylenediamine
- EC Number:
- 202-430-6
- EC Name:
- o-phenylenediamine
- Cas Number:
- 95-54-5
- Molecular formula:
- C6H8N2
- IUPAC Name:
- benzene-1,2-diamine
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Duration of treatment / exposure:
- 8 weeks
Doses / concentrations
- Dose / conc.:
- 0.8 other: mg/kg
- Details on study design:
- o-Phenylenediamine was administered daily at 0.8 mg/kg body weight to rats for 8 weeks (route, sex, number, and animal strain not cited).
Results and discussion
Results of examinations
- Details on results:
- o-Phenylenediamine decreased the number of erythrocytes and increased the serum activities of the alkaline phosphatase, aldolase, and alanine and aspartate aminotransferases.
Effect levels
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- o-Phenylenediamine decreased the number of erythrocytes and increased the serum activities of the alkaline phosphatase, aldolase, and alanine and aspartate aminotransferases.
- Executive summary:
o-Phenylenediamine decreased the number of erythrocytes and increased the serum activities of the alkaline phosphatase, aldolase, and alanine and aspartate aminotransferases.
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