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EC number: 207-079-2
CAS number: 431-89-0
The 48-h LC50 is > 100 mg/L in Daphnia magna for the structural analogues HFC 245fa and HFC 365mfc
The assessment of the possible aquatic toxicity of HFC 227ea has been
carried out by considering available data on structurally analogue
Experimental data for acute toxicity on Daphnia magna are available for
HFC 245fa (1,1,1,3,3-pentafluoropropane) and HFC 365mfc (1,1,1,2,2
In both cases, studies were conducted in closed system to avoid
Both HFC 365mfc and HFC 245fa showed a low toxicity to D. magna and no
48 -h EC50 could be identified as low immobility was observed up to the
highest tested concentrations for the other substances. Overall, a 48
-hour LC50= 100 mg/l (i.e. the lowest experimental value determined for
sturctural analogs) can be considered as a conservative estimation of
the HFC 227ea acute toxicity to aquatic invertebrates.
HFC 245fa:Pentafluoropropane was tested for acute toxicity in D.
magna following OECD Guidelines. Water fleas were exposed for 48
consecutive hours to a nominal limit concentration of 100 mg/l. A
concurrent negative control group was included in the test. The test
substance concentration was monitored at the test initiation and
termination. The average measure concentration was 97.9 mg/l HFC 245fa.
No immobility was observed in the control and treatment groups. A 48 -h
EC50 > 100 mg/l was determined.
HFC365mfc:The acute toxicity of pentafluorobutane to Daphnia
magna was tested following OECD Guidelines. Water fleas (3 replicates of
10 organisms/concentration) were exposed to 0, 100, 150, 200 mg/l
pentafluorobutane for 48 hours in a closed system to avoid the test
substance evaporation. The substance concentration in the samples was
monitored at the test initiation and termination. A difference of less
than 20% was observed among the nominal and measured concentrations.
No immobility was observed in controls. Some immobile water fleas were
observed at 150 and 200 mg/l (6.7 and 13% of immobility, respectively),
but the NOEC calculated by means of the Fisher's exact test was 200
mg/l. A NOEC of 100 mg/l was set for sublethal effects (water fleas were
lying at the bottom of the flasks after 48 h exposure to 150 and 200
mg/l). An EC50> 200 mg/l was determined. All validity criteria were
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