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EC number: 207-079-2
CAS number: 431-89-0
The following half-life times were
determined in the experiment:
Test # 1: Half-life 1st: 4.7 min (males) and
7.9 min (females)
Test # 1: Half-life 2nd: 22 min (females,
1000 and 8000 ppm) and 42 min (females, 2000 and 4000 ppm); 37 min
(males, 1000 and 8000 ppm); 62 min (males, 2000 ppm); 92 min (males,
No metabolites were identified.
Exposure of healthy volunteers to exposure
levels up to 8000 ppm HFC 227 did not result in any adverse effect on
pulse, blood pressure, electrocardiogram or lung function:
Systolic and diastolic blood pressure
measurements showed no trend for a change as a result of exposure. At
each time point, there were no statistically significant differences
between exposure to HFC 227 at any exposure level compared to air
(combined) or CFC12 (combined).
Pulse rate showed no trend or change with
time as a result of exposure. At each time point, there were no
statistically significant differences between exposure to HFC 227 at any
exposure level compared to air (combined) or CFC12 (combined).
Peak expiratory flow showed no difference
between the pre- and postexposure values. At each time point, there were
no statistically significant differences between exposure to HFC 227 at
any exposure level compared to air (combined) or CFC12 (combined).
There were no clinically relevant changes in
the ECG traces.
There were neither clinically significant
changes in any of the laboratory parameters measured nor any notable
adverse events recorded. Specifically there were no central nervous
system effects reported or observed and there was no indication of upper
respiratory tract irritation.
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