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EC number: 207-079-2
CAS number: 431-89-0
Because some aldehydes
may covalently bind to proteins and the formation of fluorinated protein
adducts has been implicated in immune-mediated hepatitis induced by
halothane, the binding of hexafluoroacetone trihydrate to proteins was
also investigated. Hexafluoroacetone trihydrate also gave only a very
small resonance in fluorine NMR experiments when binding to human serum
albumin was studied in comparison with the acylating agent
S-ethyltrifluoroacetate. Moreover, no fluorine-containing products were
formed by the reaction of hexafluoroacetone trihydrate with Nα-acetyl-L-Iysine,
and hexafluoroacetone trihydrate was not metabolized to
fluorine-containing metabolites or inorganic fluoride in rats.
Comparative studies in human liver microsomes demonstrated that a
halothane metabolite may covalently bind to proteins; in contrast,
metabolism and covalent binding of HFA 227ea could not be demonstrated.
The data indicate that
HFA-227 is biotransformed at very low rates to hexafluoroacetone
trihydrate but irreversible binding of hexafluoroacetone trihydrate
cannot be demonstrated, even with the application of very sensitive
methods, and is considered unlikely, based on the combination of the
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