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Description of key information

Oral (Acute Toxic Class Method), rat: LD50 = 500 - 2000 mg/kg bw; reliability score = 1;  BASF SE 1998

Key value for chemical safety assessment

Additional information

Acute oral toxicity

In an acute oral toxicity study performed according to EU B.1 modified according to OECD 423 (deviation: starting dose was 500 mg/kg bw instead of 300 mg/kg bw), 3 male Wistar rats were administered 500 mg/kg bw of the test substance (> 95% pure) in water per gavage as the starting dose. All animals were observed for clinical signs for 14 days and necropsied. As no animal died at 500 mg/kg bw, the same dose was tested in 3 females, respectively. No animal died, either. Subsequently 3 males were administered a dose of 2000 mg/kg bw. All animals died within 2 hours. No signs of toxicity were noted in the 500 mg/kg bw male group. Impaired and poor general state, dyspnoea, apathy, abdominal position, fibrillar contractions and piloerection were observed in the 500 mg/kg bw female group 3 - 5 hours after application. In the 2000 mg/kg bw group, poor general state, dyspnoea, apathy, staggering and twitching were observed before death. Thus, the LD50 is > 500 and < 2000 mg/kg bw. The study is suitable for assessment as it was performed according to guideline under GLP conditions (BASF SE, 1998).

 

Acute dermal toxicity

No data available.

 

Acute inhalative toxicity

No data available.

Justification for classification or non-classification

Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008

The available experimental test data are reliable and suitable for the purpose of classification. Based on the criteria laid down in Regulation (EC) No. 1272/2008, as amended for the 2nd time in Directive EC 286/2011, classification for acute oral toxicity is warranted as “category 4".