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EC number: 209-674-2
CAS number: 590-19-2
increase in relative organ weight compared to concurrent control
No of rats
significantly different from control
statistically significantly different from control p≤0.05
statistically significantly different from control p≤0.01
higher but difference from control not statistically significant
of nephropathy in male rats
Severity of nephropathy in Males
1000 ppm v/v
8000 ppm v/v
statistically significant dose related trend (p≤0.05) for "fatal"
nephropathy was established.
was defined for the statistical treatment by the Peto method of analysis.
A 2-year inhalation study was conducted in
Sprague-Dawley rats with 1,3-butadiene. Groups of 110 male and 110
female rats inhaled 1,3-butadiene at 0, 1000, or 8000 ppm for 6 hr/day,
5 days/week. Interim clinical pathology, neuromuscular, and
histopathology investigations were carried out. The study terminated at
20 to 25% survival (105 weeks for females, 111 weeks for males).
Following exposure to 1,3-butadiene there were no effects on
haematology, blood chemistry, urine analysis or neuromuscular function
that definitely could be associated with treatment. Treatment-related
non-neoplastic findings were associated with changes in clinical
condition, suppression of body weight gain, reduced survival, and
increases in certain organ weights.
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