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EC number: 209-674-2
CAS number: 590-19-2
examination revealed no signs of irritation in dogs or rabbits.
Histopathological examination revealed no effects on the cornea, sclera,
or ciliary body. None of the sections showed any indication of
degeneration of the retinal ganglion cells, and the other retinal layers
displayed no abnormality. Sections of the optic nerve with adjacent
retina stained with osmic acid showed no degeneration of myelin sheaths.
Dogs and rabbits were exposed to
1,3-butadiene for 8 months at concentrations of 600,
2300 and 6700 ppm (1327, 5098 and 14824 mg/m3) and eyes examined. No
irritation to the eyes of the dogs or rabbits occurred at any doses.
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