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EC number: 209-674-2
CAS number: 590-19-2
The results of the QSAR predictions for buta-1,2-diene indicate that it is expected to degrade rapidly, with an estimated half life of 2.36 days.
buta-1,2-diene is a gas at standard temperature and pressure conducting
a standard ready biodegradability test is technically difficult, and
based on exposure estimates the test may not be relevant. Therefore, the
use of a QSAR to predict the biodegradability of buta-1,2-diene is an
appropriate technique to use a part of a weight of evidence approach.
The use of BioHCwin and Biowin is appropriate for buta-1,2-diene as this
compound clearly falls within the applicability domains of these models
as all substructures in buta-1,2-diene are included in the models. The
results from both QSAR indicate that buta-1,2 -diene is expected to
addition, read-across to buta-1,3-diene adds to the weight of evidence
that buta-1,2-diene is rapidly biodegradable in the environment. Various
researchers have isolated microorganisms that are capable of
metabolising buta-1,3-diene (e.g. Hou et al. 1983). Although this study
does not follow standard guidelines for ready biodegradability tests
they do demonstrate that microorganisms can biodegrade buta1,3-diene in
XI of the REACH legislation states that data for an endpoint may be
omitted where testing is not technically possible. Given its high
volatility it would be very difficult to carry out a standard
biodegradation test and for the test to provide meaningful results. It
is therefore difficult to provide measured data to demonstrate the
biodegradability of buta-1,2 -diene. A proprietary study was carried out
in 2000 and reported that buta-1,2-diene was not readily biodegradable.
However, the modified Sturm test was used which is not appropriate for
volatile substances, according to OECD Test Guidelines. In addition, the
investigators had to implement conditions which would not be found in
the natural environment in order to get the buta-1,2-diene into the test
solution. On this basis, the study has been given a Klimisch score of 3
(not reliable) and will not be used.
place of measured data we have submitted data from two QSARs whose
scientific validity has been established and which have applicability
domains including buta-1,2-diene. Based on the data reported in the EU
RAR for buta-1,3-diene, the likely environmental fate of buta-1,2-diene
and the additional QSAR estimates of biodegradation rate provided here
we believe that there is sufficient weight of evidence to conclude that
buta-1,2-diene can be considered readily biodegradable for the purposes
of this risk assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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