Registration Dossier
Registration Dossier
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EC number: 210-248-3 | CAS number: 611-06-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
- Principles of method if other than guideline:
- Method: other: acute toxicity oral: male rats
- GLP compliance:
- not specified
- Test type:
- other: acute oral toxicity study
- Limit test:
- no
Test material
- Reference substance name:
- 1,3-dichloro-4-nitrobenzene
- EC Number:
- 210-248-3
- EC Name:
- 1,3-dichloro-4-nitrobenzene
- Cas Number:
- 611-06-3
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,3-dichloro-4-nitrobenzene
- Details on test material:
- IUCLID4 Test substance: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Lutrol
- Doses:
- 20 ml/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 379 mg/kg bw
Any other information on results incl. tables
SO-Freetext: Hoechst AG Frankfurt 80
Hoechst AG Frankfurt/Main
RM-Freetext:
maennlich
RM-Freetext:
Verabreichung per Magensonde, Symptome: Narkose, struppiges
Fell, Bauch- und Seitenlage, Herabsetzung des Allgemeinbe-
findens, erhoehte Diurese, keine substanzbedingten makros-
kopischen Veraenderungen.
Applicant's summary and conclusion
- Executive summary:
In an acute oral toxicity study 10 male Wistar rats were treated via gavage with 20 ml/kg bw of test substance.
Signs of intoxication were: narcosis, face-down position and lateral position, scrubby fur, diminuated general condition.
The LD 50 was 379 mg/kg bw.
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