Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

No experimental toxicokinetic study is available on Triclyclodecanedimethanol dimethacrylate. However, as per REACH guidance document R7.C (May 2012), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.
Based on the toxicological data and the physicochemical properties, the absorption of Triclyclodecanedimethanol dimethacrylate is expected to be low by oral route, dermal route and inhalation.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - oral (%):
100
Absorption rate - dermal (%):
100
Absorption rate - inhalation (%):
100

Additional information

No experimental toxicokinetic study is available on Triclyclodecanedimethanol dimethacrylate. However, as per REACH guidance document R7.C (May 2012), information on absorption, distribution, metabolisation and excretion may be deduced from the physicochemical properties, including:

-Mean molecular weight: 332.4 g/mol for 98.6% of the constituents

-Water solubility: 0.39 mg/L (slightly soluble)

-Partition coefficient (Log Kow): 5.8

-Vapour pressure: 0.0109 Pa

 

ABSORPTION

The high value of log Kow (>4) and the low solubility (<100 mg/L) of Triclyclodecanedimethanol dimethacrylate are favorable for a low oral absorption. An oral absorption is expected to be low for Triclyclodecanedimethanol dimethacrylate.

With a solubility of 0.39 mg/L, dermal absorption is anticipated to be low. A Log Kow of 5.8 suggests that the rate of penetration of the substance my be limited by the rate of transfer between the stratum corneum and the epidermis. However, a molecular mass smaller than 500 g/mol are favourable to a dermal absorption. The acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Indeed, the dermal absorption of Triclyclodecanedimethanol dimethacrylate is anticipated to be low. However, Triclyclodecanedimethanol dimethacrylate showed allergic reaction in the skin sensitisation study: it is evidence that some uptake must have occurred although it may only have been a small fraction of the applied dose.

Based on the low value of the vapour pressure (<0.1 Pa), Triclyclodecanedimethanol dimethacrylate is not considered as a volatile substance. Moreover, the absorption by inhalation can be expected to be low for Triclyclodecanedimethanol dimethacrylate based on the values of water solubility and log kow.

 

DISTRIBUTION and METABOLISM

No specific data is available on the distribution or metabolism of Triclyclodecanedimethanol dimethacrylate.

 

ELIMINATION

Due to the low water solubility and the moderate molecular mass, the excretion of Triclyclodecanedimethanol dimethacrylate in the urines is expected to be low. An excretion via bile and faeces is possible.