Registration Dossier
Registration Dossier
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EC number: 200-941-9 | CAS number: 76-19-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- Data from reports from 1982 to 2011
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Octafluoropropane is a gas, making testing technically difficult. However, as the attached reports explains, it can be considered a saturated perfluorocarbon, a class of compounds with near identical toxicology properties.
We have several toxicity reports supporting our position; the details in this end point are taken from the first, which is also the most recent.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
Materials and methods
- Principles of method if other than guideline:
- SkinEthic exposed to subject material for 10 minutes. Viability of cells determined by their ability to reduce MTT. scored out of 100.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1,1,2,2,3,3,4,5,5,5-undecafluoro-4-(trifluoromethyl)pentane
- EC Number:
- 206-575-6
- EC Name:
- 1,1,1,2,2,3,3,4,5,5,5-undecafluoro-4-(trifluoromethyl)pentane
- Cas Number:
- 355-04-4
- Molecular formula:
- C6F14
- IUPAC Name:
- 1,1,1,2,2,3,3,4,5,5,5-Undecafluoro-4-(trifluoromethyl)pentane
- Test material form:
- liquid: volatile
Constituent 1
Test animals / tissue source
- Species:
- other: SkinEthic
Test system
- Vehicle:
- unchanged (no vehicle)
Results and discussion
In vitro
Results
- Irritation parameter:
- other: Relativity viability
- Value:
- >= 93.2 - < 93.3
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on studies with other unsaturated perfluorocarbons, we can be confident octafluoropropane is not an eye irritant.
- Executive summary:
Based on studies with other unsaturated perfluorocarbons, together with experience of its use as a device in eye surgury, we can be confident octafluoropropane is not an eye irritant.
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