Registration Dossier
Registration Dossier
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EC number: 200-941-9 | CAS number: 76-19-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- Octafluoropropane is a gas, making testing difficult. However, numerous studies have shown that saturated perfluorocarbons as a class as not irritating to skin.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- EPISKIN(TM) reconstructed human epidermis was treated for a period of 15 minutes, followed by an incubation period of 42 hours. Cell viability was measured colorimetrically by the enzymatic reduction of yellow MTT tetrazolium salt.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1,1,2,2,3,3,4,5,5,5-undecafluoro-4-(trifluoromethyl)pentane
- EC Number:
- 206-575-6
- EC Name:
- 1,1,1,2,2,3,3,4,5,5,5-undecafluoro-4-(trifluoromethyl)pentane
- Cas Number:
- 355-04-4
- Molecular formula:
- C6F14
- IUPAC Name:
- 1,1,1,2,2,3,3,4,5,5,5-Undecafluoro-4-(trifluoromethyl)pentane
- Test material form:
- liquid: volatile
Constituent 1
In vitro test system
- Test system:
- human skin model
- Source species:
- human
- Cell type:
- non-transformed keratinocytes
- Vehicle:
- unchanged (no vehicle)
- Control samples:
- yes, concurrent negative control
- yes, concurrent positive control
- Amount/concentration applied:
- 10 microlitre
- Duration of treatment / exposure:
- 15 minutes
- Duration of post-treatment incubation (if applicable):
- 42 hours
- Number of replicates:
- 3
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- mean
- Value:
- ca. 91.7
- Remarks on result:
- no indication of irritation
- Other effects / acceptance of results:
- The relative mea viability of the test item treated tissues was 91.7% after a 15 minute exposure period. The quality criteria for acceptance of results in the test were satisfied.
Applicant's summary and conclusion
- Conclusions:
- The test item was considered to be non-irritant. Together with the results from other saturated perfluorocarbons, we can be confident octafluoropropane is not irritating.
- Executive summary:
Octafluoropropane is non-irritant.
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