Registration Dossier
Registration Dossier
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EC number: 203-862-8 | CAS number: 111-36-4
Endpoint summary
Administrative data
Description of key information
skin irritation: substance was applied into the inside of the ear of a rabbit; result: highly corrosive
eye irritation: the undiluted substance was placed into the conjunctival sac of a rabbit; result: highly corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
n-Butyl isocyanate is corrosive to skin and eyes of rabbits. The toxicity studies and one case report indicate that n-butyl isocyanate vapor causes irritation of the respiratory tract. RD50 values for rat and mice of 40.4 mg/m³ and 38.9 mg/m³, respectively, were determined and gave evidence for a moderate sensory irritation potential of n-butyl isocyanate. 1 mg/m³ (RD50 x 0.03) was regarded as the threshold for sensory irritation in humans.
Effects on skin irritation/corrosion: highly corrosive
Effects on eye irritation: highly corrosive
Justification for classification or non-classification
due to the results of the key study for skin irritation/corrosion R34 is justified
due to the severe effects on the eye R41 is adequate; however as the substance is labelled with R34 and additional labelling with R41 is not necessary.
Therefore for skin and eye irritation/corrosion a labelling with R34 is sufficient
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