Registration Dossier
Registration Dossier
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EC number: 203-862-8 | CAS number: 111-36-4
Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: unsuitable test system
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicity of benomyl and some related 2-substituted benzimidazoles to the earthworm Lumbricus terrestris.
- Author:
- Stringer A, Wright MA
- Year:
- 1 976
- Bibliographic source:
- Pestic. Sci. 7, 459-464.
Materials and methods
- Principles of method if other than guideline:
- Method: other: Inhibition of cholinesterase activity
- GLP compliance:
- no
Test material
- Reference substance name:
- Butyl isocyanate
- EC Number:
- 203-862-8
- EC Name:
- Butyl isocyanate
- Cas Number:
- 111-36-4
- Molecular formula:
- C5H9NO
- IUPAC Name:
- 1-isocyanatobutane
- Details on test material:
- IUCLID4 Test substance: other TS: Butyl isocyanate, no purity specified, but freshly distilled
Constituent 1
Test organisms
- Test organisms (species):
- other: Lumbricus terrestris
Results and discussion
Effect concentrations
- Duration:
- 75 min
- Dose descriptor:
- EC50
- Effect conc.:
- 3 other: mg/l
- Basis for effect:
- other: Inhibition of enzyme activity
Any other information on results incl. tables
RS-Freetext:
n-Butyl isocyanate inhibited in vitro cholinesterase activity with an IC50 of approximately 3 +/- 0.1 mg/l (30.3 +/- 1.06 µM)
Applicant's summary and conclusion
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