Registration Dossier
Registration Dossier
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EC number: 203-862-8 | CAS number: 111-36-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- ADMINISTRATION: vapor inhalation under dynamic head-nose only exposure conditions post observation period: approx. 4 weeks nominal concentrations: 13; 21; 54; 83; 108; 187; 399; 1077 mg/m³ analytical concentrations: 3.1; 7.2; 31.7; 55.6; 63.6; 109.8; 270.3; 861.9 mg/m³ EXAMINATIONS: mortality; clinical signs; body weight; rectal temperature,reflex, necropsy
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Butyl isocyanate
- EC Number:
- 203-862-8
- EC Name:
- Butyl isocyanate
- Cas Number:
- 111-36-4
- Molecular formula:
- C5H9NO
- IUPAC Name:
- 1-isocyanatobutane
- Details on test material:
- n-butyl isocyanate, purity: 99.5 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 3, 7, 32, 56, 64, 110, 270, 862 mg/m³ (analytical)
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 59 mg/m³ air
- Exp. duration:
- 4 h
- Mortality:
- Number of deaths at each dose (time of death), male rats: 3 mg/m³: 0/5; 7 mg/m³: 0/5; 32 mg/m³: 0/5; 56 mg/m³: 0/5; 64 mg/m³: 4/5 (10d-14d); 110 mg/m³: 5/5 (2d-9d); 270 mg/m³: 5/5 (1d-2d); 862 mg/m³: 5/5 (<4h) Number of deaths at each dose (time of death), female rats: 3 mg/m³: 0/5; 7 mg/m³: 0/5; 32 mg/m³: 0/5; 56 mg/m³: 3/5 (9d-19d); 64 mg/m³: 3/5 (11d-15d); 110 mg/m³: 5/5 (8d-16d); 270 mg/m³: 5/5 (1d-8d); 862 mg/m³: 5/5 (4h/1d)
- Clinical signs:
- other: Number of animals with clinical signs, male rats: 3 mg/m³: 0/5; >= 7 mg/m³: 5/5 showed during the exposure and up to 28d after the exposure decreased motility, piloerection, exsudate of nostris, cyanosis; rhinitis like vocalization, labored breathing, br
- Body weight:
- BODY WEIGHT: >= 32 mg/m³: body weight retardation
- Gross pathology:
- NECROPSY: rats died during the post observation period: distended lungs, pale liver, spleen, and kidneys, gastrointestinal tract was filled with a yellow mucous or bloody mucous mass, reddening of the intestinal mucosa, sporadic ulcus like foci in intestinal mucosa, lobular pattern of the liver, pulmonary edema, and hydrothorax; liver like changes in the lung; blood-incrusted and reddened noses with serous discharge rats sacrificed at the end of the post observation period: no lung lesions in the control and 3 mg/m³ dose group animals; the animals of the other dose groups showed significant gross findings in the lung
- Other findings:
- REFLEX EXAMINATION: no substance induced effects
RECTAL TEMPERATURE: concentration dependent decrease
VALUE: NOEL = 3 mg/m³ the LC50-value is true for both sexes
Any other information on results incl. tables
the LC50-value is true for both sexes
Applicant's summary and conclusion
- Interpretation of results:
- highly toxic
- Remarks:
- Migrated information
- Executive summary:
ADMINISTRATION:
vapor inhalation under dynamic head-nose only exposure conditions
post observation period: approx. 4 weeks
nominal concentrations: 13; 21; 54; 83; 108; 187; 399; 1077 mg/m³
analytical concentrations: 3.1; 7.2; 31.7; 55.6; 63.6; 109.8; 270.3; 861.9 mg/m³
EXAMINATIONS:
mortality; clinical signs; body weight; rectal temperature,reflex, necropsyLC50 = 59 mg/m³ (rat, male/female)
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