2,2,2-trichloroethane-1,1-diol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Acute, single exposure

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Primary source from peer-reviewed journal.
Handbook source from United Nations CICAD report, Concise International Chemical Assessment Document 25, 2000
The substance carries a harmonised classification for acute oral toxicity

Data source

Reference

Reference Type:

publication

Title:

Fate of 2,2,2-trichloroacetaldehyde, (chloral hydrate) produced during trichloroethylene, oxidation by methanotrophs

Author:

Newman LM, Wackett LP

Year:

1991

Bibliographic source:

Applied and environmental microbiology, 57:2399–2402

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Version / remarks:

Mice

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,2,2-trichloroethane-1,1-diol

EC Number:

206-117-5

EC Name:

2,2,2-trichloroethane-1,1-diol

Cas Number:

302-17-0

Molecular formula:

C2H3Cl3O2

IUPAC Name:

2,2,2-trichloroethane-1,1-diol

Test material form:

solid: granular

Test animals

Species:

mouse

Strain:

CD-1

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Doses:

300, 600, 900, 1200, 1500, and 1800 mg/kg body weight

No. of animals per sex per dose:

8 male, 8 female

Control animals:

not specified

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD0

Effect level:

ca. 900 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

ca. 1 265 mg/kg bw

Based on:

test mat.

Effect levels 3

Sex:

male

Dose descriptor:

LD50

Effect level:

ca. 1 442 mg/kg bw

Based on:

test mat.

Effect levels 4

Key result

Sex:

male/female

Dose descriptor:

discriminating dose

Effect level:

< 300 mg/kg bw

Based on:

test mat.

Remarks on result:

other: Sedation observed at all dose levels and considered to be an adverse effect

Mortality:

Yes, at higher dose groups and all within 24 hours of administration
No mortality at 900 mg/kg or lower

Clinical signs:

other: Yes; lethagy and sedation observed within minutes of administration

Gross pathology:

None reported

Other findings:

Sedation occured at 300 mg/kg and higher, with effects observed within minutes of administration.

Any other information on results incl. tables

The mice became sedated at 300 mg/kg body weight. At 600 and 900 mg/kg the animals became lethargic and exhibited loss of righting reflex.

Respiration was markedly inhibited at 1200, 1500, and 1800 mg/kg.

Inhibition of respiration appeared to be the immediate cause of death

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

Other acute oral studies are cited in the UN CICAD report, with Rat LD50 considered to be 480 mg/kg.
In view of the harmonised classification, further testing is not justified.