2,2,2-trichloroethane-1,1-diol

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authoritative database

Data source

Reference

Reference Type:

other: authoritative database

Title:

Eye Irritation data for chloral hydarate

Author:

U.S. National Library of Medicine

Year:

2018

Bibliographic source:

HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Chloral hydrate eye irritation data from HSDB database

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2,2,2-trichloroethane-1,1-diol

EC Number:

206-117-5

EC Name:

2,2,2-trichloroethane-1,1-diol

Cas Number:

302-17-0

Molecular formula:

C2H3Cl3O2

IUPAC Name:

2,2,2-trichloroethane-1,1-diol

Test material form:

solid: crystalline

Details on test material:

- Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid

Specific details on test material used for the study:

- Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid

Test animals / tissue source

Species:

other: not specified

Strain:

not specified

Details on test animals or tissues and environmental conditions:

not specified

Test system

Vehicle:

not specified

Amount / concentration applied:

not specified

Duration of treatment / exposure:

not specified

Observation period (in vivo):

not specified

Duration of post- treatment incubation (in vitro):

not specified

Number of animals or in vitro replicates:

not specifiednot specified

Details on study design:

not specified

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Remarks on result:

other: Moderate doses affects eye movements, particularly interfering with convergence, and sometimes causing ptosis. It may cause swelling of lids, hyperemia and edema of the conjunctivae, plus a sensation of irritation and tearing.

Irritant / corrosive response data:

Moderate doses affects eye movements, particularly interfering with convergence, and sometimes causing ptosis. It may cause swelling of lids, hyperemia and edema of the conjunctivae, plus a sensation of irritation and tearing.

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritating to eyes) based on GHS criteria

Conclusions:

Moderate dose of chloral hydrate is found to irritating to the eye.

Executive summary:

Moderate doses of chloral hydrate affects eye movements, particularly interfering with convergence, and sometimes causing ptosis. It may cause swelling of lids, hyperemia and edema of the conjunctivae, plus a sensation of irritation and tearing. GHS classification of the substance also indicates the substance to be irritating to eye and hence classified as Eye irritant 2.