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EC number: 252-552-9
CAS number: 35415-27-1
A Combined repeated
dose toxicity study with reproduction/developmental toxicity screening
was conducted for 1,2, 4 benzenetricarboxlyic acid, trioctyl ester
(C8TM) at 0 (carrier), 30, 125 and 500 mg/kg for both female and male
animals, with repeated administration in Sprague Dawley female and male
rats (13 animals each/group) from 2 weeks before mating up until mating,
then for 42 days for males and for pregnant females throughout gestation
until day 4 of lactation. This GLP conform study was performed according
to OECD testing guideline 422.
Other than 1 female
death in the 500 mg/kg group at 23 days gestation, no deaths were
recorded. In terms of changes in general condition, salivation was
observed in both males and females directly following administration in
the 500 mg/kg group. In females in the 500 mg/kg group, body weight
increase values were low at 7-14 days gestation, but there was no
influence of the test substance on male body weight or male and female
food intake. In females, there was a reduction in red blood cell count
and an increase in liver weight in the 125 mg/kg group, and decreased
plasma protein concentration and increased glucose concentration in the
500 mg/kg group. Males in the 500 mg/kg group showed decreased serum
protein and elevated alkaline phosphatase activity. Histological
findings showed centrilobular liver hypertrophy in males in the 500
mg/kg group, but no reproductive system abnormalities thought to be
caused by administration of the test substance were noted.
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