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EC number: 252-552-9
CAS number: 35415-27-1
The in vitro skin absorption of triethylhexyl trimellitate was
determined via analytical methods in Franz cells using full-thickness
skin samples excised from female nude mice and specific pathogen-free
pigs. The receptor medium contained 40% ethanol, and the donor medium
was 5.4 mM triethylhexyl trimellitate in 40% ethanol/pH 7.4 buffer. The
skin samples were removed from the cells after a 12 h exposure and
tape-stripped. The accumulation of triethylhexyl trimellitate was 1.32 ±
0.53 nmol/mg in nude mouse and 0.35 ± 0.19 nmol/mg in pig skin; the flux
was 0 nmol/cm2/h for both mouse and pig skin. Triethylhexyl trimellitate
was not found in the receptor medium after 12 h, indicating no
biologically relevant availability for dermal absorption.
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